2023
Flashner S*, Shimonosono S*, Tomita Y, Matsuura N, Ohashi S, Klein-Szanto AJ, Diehl JA, Chen CH, Mochly-Rosen D, Nakagawa H. ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment. Carcinogenesis. doi: 10.1093/carcin. *equal contribution. Full Text | Preprint
Parikh AS, Yu VX, Flashner S, Okolo OB, Lu C, Henick BS, Momen-Heravi F, Puram SV, Teknos T, Pan Q, Nakagawa H. Patient-derived three-dimensional culture techniques model tumor heterogeneity in head and neck cancer. Oral Oncol. 2023 Feb 9;138:106330. doi: 10.1016/j.oraloncology.2023.106330. PMID: 36773387. Full Text
Okolo O, Yu V, Flashner S, Martin C, Nakagawa H, Lin DT, Puram SV, Parikh AS. Protocol for tumor dissociation and fluorescence-activated cell sorting of human head and neck cancers. STAR Protocols. 2023 Jun 16;4(2):102294. PMID: 37149858. Full Text
Okolo O, Honzel E, Britton WR, Yu VX, Flashner S, Martin C, Nakagawa H, Parikh AS. Experimental Modeling of Host–Bacterial Interactions in Head and Neck Squamous Cell Carcinoma. Cancers. 2023; 15(24):5810. https://doi.org/10.3390/cancers15245810. Full Text
2022
Flashner S, Swift M, Sowash A, Fahmy AN, Azizkhan-Clifford J. Transcription factor Sp1 regulates mitotic chromosome assembly and segregation. Chromosoma. 2022 Sep;131(3):175-191. doi: 10.1007/s00412-022-00778-z. Epub 2022 Aug 2. PMID: 35916925; PMCID: PMC9470683. Full Text | PDF
Flashner S*, Martin C*, Matsuura N, Shimonosono M, Tomita Y, Morimoto M, Okolo O, Yu VX, Parikh AS, Klein-Szanto AJ, Yan K, Gabre JT, Lu C, Momen-Heravi F, Rustgi AK, Nakagawa H. Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids. J. Vis. Exp. (190), e64676, doi:10.3791/64676 (2022). *equal contribution. Full Text | PDF
Doyle AD, Masuda MY, Pyon GC, Luo H, Putikova A, LeSuer WE, Flashner S, Rank MA, Nakagawa H, Kita H, Wright BL. Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus. Allergy. 2022 Jul 28. doi: 10.1111/all.15457. PMID: 35899466. Full Text
Mucha B, Qie S, Bajpai S, Tarallo V, Diehl JN, Tedeschi F, Zhou G, Gao Z, Flashner S, Klein-Szanto AJ, Hibshoosh H, Masataka S, Chajewski OS, Majsterek I, Pytel D, Hatzoglou M, Der CJ, Nakagawa H, Bass AJ, Wong KK, Fuchs SY, Rustgi AK, Jankowsky E, Diehl JA. Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation. Nat Commun. 2022 Nov 3;13(1):6614. doi: 10.1038/s41467-022-34402-6. PMID: 36329064; PMCID: PMC9633729. Full Text
2021
Flashner S, Yan KS, Nakagawa H. 3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers. Microorganisms. 2021 Oct 20;9(11):2182. doi: 10.3390/microorganisms9112182. PMID: 34835308; PMCID: PMC8622040. Full Text | PDF
Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl JA, Nakagawa H. Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. Biomolecules. 2021 Oct 7;11(10):1479. doi: 10.3390/biom11101479. PMID: 34680112; PMCID: PMC8533166. Full Text | PDF
Swift ML, Beishline K, Flashner S, Azizkhan-Clifford J. DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1. Cell Rep. 2021 Mar 16;34(11):108840. doi: 10.1016/j.celrep.2021.108840. PMID: 33730584. Full Text | PDF
Sachdeva UM, Shimonosono M, Flashner S, Cruz-Acuña R, Gabre JT, Nakagawa H. Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Lett. 2021 Jul 1;509:39-52. doi: 10.1016/j.canlet.2021.03.031. Epub 2021 Apr 7. PMID: 33838281; PMCID: PMC8493518. Full Text
2018
Torabi B, Flashner S, Beishline K, Sowash A, Donovan K, Bassett G, Azizkhan-Clifford J. Caspase cleavage of transcription factor Sp1 enhances apoptosis. Apoptosis. 2018 Jan;23(1):65-78. doi: 10.1007/s10495-017-1437-4. PMID: 29236199. Full Text